Recent advances in the understanding of trimeric autotransporter adhesins.

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ID: 73306
2019
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Abstract
Adhesion is the initial step in the infection process of gram-negative bacteria. It is usually followed by the formation of biofilms that serve as a hub for further spread of the infection. Type V secretion systems engage in this process by binding to components of the extracellular matrix, which is the first step in the infection process. At the same time they provide protection from the immune system by either binding components of the innate immune system or by establishing a physical layer against aggressors. Trimeric autotransporter adhesins (TAAs) are of particular interest in this family of proteins as they possess a unique structural composition which arises from constraints during translocation. The sequence of individual domains can vary dramatically while the overall structure can be very similar to one another. This patchwork approach allows researchers to draw conclusions of the underlying function of a specific domain in a structure-based approach which underscores the importance of solving structures of yet uncharacterized TAAs and their individual domains to estimate the full extent of functions of the protein a priori. Here, we describe recent advances in understanding the translocation process of TAAs and give an overview of structural motifs that are unique to this class of proteins. The role of BpaC in the infection process of Burkholderia pseudomallei is highlighted as an exceptional example of a TAA being at the centre of infection initiation.
Reference Key
kiessling2019recentmedical Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Kiessling, Andreas R;Malik, Anchal;Goldman, Adrian;
Journal medical microbiology and immunology
Year 2019
DOI
10.1007/s00430-019-00652-3
URL
Keywords
protein structure burkholderia pseudomallei gram-negative bacteria protein folding protein transport protein translocation adhesins autotransport autotransporter bam bacterial outer membrane proteins bacterial proteins bpac outer membrane protein export protein secretion transmembrane β-barrel trimeric autotransporter adhesins (taas) type v secretion virulence factors/chemistry

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