Phenotypic and Functional Analysis of Human NK Cell Subpopulations According to the Expression of FcεRIγ and NKG2C.

Clicks: 472
ID: 73304
2019
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Steady

Ranked #7 of 111 articles by views in Frontiers in immunology

Most read Least read

Bar heights use a square-root scale.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Human memory-like NK cells are commonly defined by either a lack of FcεRIγ or gain of NKG2C expression. Here, we investigated the heterogeneity of human CD56 NK cell subpopulations according to the expression of FcεRIγ and NKG2C in a large cohort ( = 127). Although the frequency of FcεRIγ and NKG2C NK cells positively correlated, the FcεRIγ and NKG2C NK cell populations did not exactly overlap. The FcεRIγNKG2C, FcεRIγNKG2C, and FcεRIγNKG2C NK cell populations were only evident after HCMV infection, but each had distinct characteristics. Among the subpopulations, FcεRIγNKG2C NK cells exhibited the most restricted killer immunoglobulin-like receptor repertoire, suggesting clonal expansion. Moreover, FcεRIγNKG2C NK cells exhibited the lowest Ki-67 and highest Bcl-2 expression, indicating the long-lived quiescent memory-like property. Functionally, FcεRIγNKG2C NK cells had weak natural effector function against K562 but strong effector functions by CD16 engagement, whereas FcεRIγNKG2C NK cells had strong effector functions in both settings. Anatomically, the FcεRIγNKG2C, FcεRIγNKG2C, and FcεRIγNKG2C NK cell populations were present in multiple human peripheral organs. In conclusion, we demonstrate the heterogeneity of memory-like NK cells stratified by FcεRIγ and NKG2C and suggest both markers be utilized to better define these cells.
Reference Key
kim2019phenotypicfrontiers Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Kim, Kyung Hwan;Yu, Hee Tae;Hwang, Ilwoong;Park, Sungha;Park, Su-Hyung;Kim, Sungjin;Shin, Eui-Cheol;
Journal Frontiers in immunology
Year 2019
DOI
10.3389/fimmu.2019.02865
URL
Keywords
human memory cytomegalovirus fcεriγ nk cell nkg2c

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.