Spatial models of cell distribution in human lumbar dorsal root ganglia.

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ID: 72350
2019
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Abstract
Dorsal root ganglia (DRG), which contain the somata of primary sensory neurons, have increasingly been considered as novel targets for clinical neural interfaces, both for neuroprosthetic and pain applications. Effective use of either neural recording or stimulation technologies requires appropriate spatial position relative to the target neural element, whether axon or cell body. However, the internal three-dimensional spatial organization of human DRG neural fibers and somata has not been quantitatively described. In this study, we analyzed 202 cross-sectional images across the length of 31 human L4 and L5 DRG from 10 donors. We used a custom semi-automated graphical user interface to identify the locations of neural elements in the images and normalize the output to a consistent spatial reference for direct comparison by spinal level. By applying a recursive partitioning algorithm, we found that the highest density of cell bodies at both spinal levels could be found in the inner 85% of DRG length, the outer-most 25-30% radially, and the dorsal-most 69-76%. While axonal density was fairly homogeneous across the DRG length, there was a distinct low density region in the outer 7-11% radially. These findings are consistent with previous qualitative reports of neural distribution in DRG. The quantitative measurements we provide will enable improved targeting of future neural interface technologies and DRG-focused pharmaceutical therapies, and provide a rigorous anatomical description of the bridge between the central and peripheral nervous systems. This article is protected by copyright. All rights reserved.
Reference Key
sperry2019spatialthe Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Sperry, Zachariah J;Graham, Robert D;Peck-Dimit, Nicholas;Lempka, Scott F;Bruns, Tim M;
Journal the journal of comparative neurology
Year 2019
DOI
10.1002/cne.24848
URL
Keywords
humans dorsal root ganglion cell density cross-sectional anatomy rrid:ab_2149620 rrid:scr_001622 rrid:scr_003070 rrid:scr_005043 rrid:scr_014242

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