Prohibitin 2: At a communications crossroads.

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2015
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Abstract
Prohibitins (PHBs) are a highly conserved class of proteins first discovered as inhibitors of cellular proliferation. Since then PHBs have been found to have a significant role in transcription, nuclear signaling, mitochondrial structural integrity, cell division, and cellular membrane metabolism, placing these proteins among the key regulators of pathologies such as cancer, neuromuscular degeneration, and other metabolic diseases. The human genome encodes two PHB proteins, prohibitin 1 (PHB1) and prohibitin 2 (PHB2), which function not only as a heterodimeric complex, but also independently. While many previous reviews have focused on the better characterized prohibitin, PHB1, this review focuses on PHB2 and new data concerning its cellular functions both in complex with PHB1 and independent of PHB1.
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bavelloni2015prohibitiniubmb Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Bavelloni, Alberto;Piazzi, Manuela;Raffini, Mirco;Faenza, Irene;Blalock, William L;
Journal iubmb life
Year 2015
DOI
10.1002/iub.1366
URL
Keywords
Cancer Diabetes inflammation stress transcription mitochondria gene regulation differentiation prohibitin myositis alzheimer's akt camk iv nucleus plasma membrane receptors

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