Facile Fabrication of Magnetic Microrobots Based on Spirulina Templates for Targeted Delivery and Synergistic Chemo-Photothermal Therapy.

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ID: 71937
2019
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Abstract
Magnetic microrobots can be actuated in fuel-free conditions and are envisioned for biomedical applications related to targeted delivery and therapy in a minimally invasive manner. However, mass fabrication of microrobots with precise propulsion performance and excellent therapeutic efficacy is still challenging, especially in a predictable and controllable manner. Herein, we propose a facile technique for mass production of magnetic microrobots with multiple functions using Spirulina ( Sp.) as biotemplate. Core-shell-structured Pd@Au nanoparticles (NPs) were synthesized in Sp. cells by electroless deposition, working as photothermal conversion agents. Subsequently, the FeO NPs were deposited onto the surface of the obtained (Pd@Au)@ Sp. particles via a sol-gel process, enabling them to be magnetically actuated. Moreover, the anticancer drug doxorubicin (DOX) was loaded on the (Pd@Au)/FeO@ Sp. microrobots, which endows them with additional chemotherapeutic efficacy. The as-prepared biohybrid (Pd@Au)/FeO@ Sp.-DOX microrobots not only possess efficient propulsion performance with the highest speed of 526.2 μm/s under a rotating magnetic field but also have enhanced synergistic chemo-photothermal therapeutic efficacy. Furthermore, they can be structurally disassembled into individual particles under near-infrared (NIR) laser irradiation and exhibit pH- and NIR-triggered drug release. These intriguing properties enable the microrobots to be a very promising and efficient platform for drug loading, targeted delivery, and chemo-photothermal therapy.
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wang2019facileacs Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Wang, Xu;Cai, Jun;Sun, Lili;Zhang, Shuo;Gong, De;Li, Xinghao;Yue, Shuhua;Feng, Lin;Zhang, Deyuan;
Journal ACS applied materials & interfaces
Year 2019
DOI
10.1021/acsami.8b15586
URL
Keywords
targeted delivery drug loading spirulina chemo-photothermal therapy magnetic microrobots

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