Technological Challenges and Future Issues for the Detection of Circulating MicroRNAs in Patients With Cancer.

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ID: 71408
2019
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Ranked #13 of 234 articles by views in Frontiers in chemistry

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Abstract
In the era of precision medicine, the success of clinical trials, notably for patients diagnosed with cancer, strongly relies on biomarkers with pristine clinical value but also on robust and versatile analytical technologies to ensure proper patients' stratification and treatment. In this review, we will first address whether plasmatic and salivary microRNAs can be considered as a reliable source of biomarkers for cancer diagnosis and prognosis. We will then discuss the pre-analytical steps preceding miRNA quantification (from isolation to purification), and how such process could be biased and time-consuming. Next, we will review the most recent tools derived from micro- and nano-technologies for microRNA detection available to date and how they may compete with current standards. This review will prioritize publications using relevant biological samples. The significance of various physical transduction schemes (mechanical, optical, electrical, etc.) for biological detection will be compared, and pros and cons of each method will be widely discussed. Finally, we will debate on how micro and nanotechnologies could widespread the use of biomarkers in modern medicine, to help manage patients with serious diseases such as cancer.
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cacheux2019technologicalfrontiers Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Cacheux, Jean;Bancaud, Aurélien;Leichlé, Thierry;Cordelier, Pierre;
Journal Frontiers in chemistry
Year 2019
DOI
10.3389/fchem.2019.00815
URL
Keywords
Cancer sample preparation mirna biosensors micro- and nano-technology

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