Soft Sensor-Based Monitoring and Efficient Control Strategies of Biomass Concentration for Continuous Cultures of and Their Application to an Industrial Production Chain.

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ID: 71056
2019
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Abstract
Continuous bioprocessing using cell retention allows the achievement of high space-time yields for slow-growing organisms such as halophiles. However, the lack of efficient methods for monitoring and control limits the application of biotechnological processes in the industry. The aim of this study was to implement a control and online monitoring strategy for biomass in continuous cultures. For the first time, a feedforward cultivation strategy in a membrane-based cell retention system allowed to control the biomass concentration of the extreme halophilic at defined levels. Moreover, soft sensor-based biomass estimation allowed reliable monitoring of biomass online. Application of the combined monitoring and control strategy using industrial process water containing formate, phenol, aniline and 4,4'-methylenedianiline could for the first time demonstrate high throughput degradation in this extremophilic bioremediation process, obtaining degradation efficiencies of up to 100%. This process demonstrates the usefulness of continuous halophilic cultures in a circular economy application.
Reference Key
mainka2019softmicroorganisms Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Mainka, Thomas;Mahler, Nicole;Herwig, Christoph;Pflügl, Stefan;
Journal Microorganisms
Year 2019
DOI
E648
URL
Keywords
bioremediation halophiles haloferax mediterranei continuous bioprocessing with cell retention soft sensor-based process monitoring hypertension metabolic syndrome insulin resistance type 2 diabetes oxidative stress visceral obesity α-lipoic acid

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