Identification and Isolation of Active Compounds from that Improve Insulin Secretion by Regulating Pancreatic β-Cell Metabolism.

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ID: 71001
2019
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Abstract
In type 2 diabetes (T2D), insufficient secretion of insulin from the pancreatic β-cells contributes to high blood glucose levels, associated with metabolic dysregulation. Interest in natural products to complement or replace existing antidiabetic medications has increased. In this study, we examined the effect of extract (ASME) and its compounds - on glucose-stimulated insulin secretion (GSIS) from pancreatic β-cells. ASME and compounds - isolated from stimulated insulin secretion in INS-1 cells without inducing cytotoxicity. A further experiment showed that compounds , , and enhanced the phosphorylation of total insulin receptor substrate-2 (IRS-2), phosphatidylinositol 3-kinase (PI3K), and Akt, and activated pancreatic and duodenal homeobox-1 (PDX-1) and peroxisome proliferator-activated receptor-γ (PPAR-γ), which are associated with β-cell function and insulin secretion. The data suggest that two isoflavonoids ( and and a nucleoside (compound ), isolated from the roots of , have the potential to improve insulin secretion in β-cells, representing the first step towards the development of potent antidiabetic drugs.
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lee2019identificationbiomolecules Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Lee, Dahae;Lee, Da Hye;Choi, Sungyoul;Lee, Jin Su;Jang, Dae Sik;Kang, Ki Sung;
Journal Biomolecules
Year 2019
DOI
E618
URL
Keywords
insulin astragalus membranaceus akt pi3k pdx-1 pparγ

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