Trace elements in schizophrenia: a systematic review and meta-analysis of 39 studies (N = 5151 participants).

Clicks: 501
ID: 70792
2019
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Popular

Ranked #1 of 37 articles by views in nutrition reviews

Most read Least read

Bar heights use a square-root scale.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
The pathogenesis of schizophrenia appears to be multifaceted.The aim of this meta-analysis of studies that investigated blood and hair concentrations of trace elements in people diagnosed with schizophrenia was to determine whether levels of trace elements in patients with schizophrenia differ from those in healthy individuals.The PubMed, Scopus, and Web of Science databases were searched to January 2018.Studies that compared concentrations of trace elements in patients with schizophrenia with those in healthy controls, in patients with schizophrenia under different treatment regimens, or in patients with schizophrenia at different stages of disease were included.Data on study and sample characteristics and measures of trace elements were extracted.Thirty-nine studies with a total of 5151 participants were included. Meta-analysis of combined plasma and serum data showed higher levels of copper, lower levels of iron, and lower levels of zinc among patients with schizophrenia vs controls without schizophrenia. Subgroup analyses confirmed the following: higher levels of copper in plasma, in users of typical antipsychotic drugs, and in males; lower levels of zinc in serum, in patients in Asia, in drug-naive/drug-free patients, and in inpatients; lower levels of iron in serum, in patients in Asia, in drug-naive/drug-free patients, in patients on antipsychotic drugs, in inpatients, in patients with acute or newly diagnosed schizophrenia, in patients with chronic or previously diagnosed schizophrenia, and in males; and lower levels of manganese in plasma and in patients with chronic or previously diagnosed schizophrenia.This meta-analysis provides evidence of an excess of copper, along with deficiencies of zinc, iron, and manganese, in patients with schizophrenia.
Reference Key
saghazadeh2019tracenutrition Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Saghazadeh, Amene;Mahmoudi, Maryam;Shahrokhi, Shayan;Mojarrad, Maryam;Dastmardi, Maedeh;Mirbeyk, Mona;Rezaei, Nima;
Journal nutrition reviews
Year 2019
DOI
nuz059
URL
Keywords
meta-analysis systematic review Zinc schizophrenia chromium selenium iron manganese copper

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.