Octave band noise exposure: Laboratory models and otoprotection efforts.

Clicks: 427
ID: 70457
2019
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Abstract
With advances in the understanding of mechanisms of noise injury, the past 30 years have brought numerous efforts to identify drugs that prevent noise-induced hearing loss (NIHL). The diverse protocols used across investigations have made comparisons across drugs difficult. A systematic review of the literature by Hammill [(2017). Doctoral thesis, The University of Texas at Austin] identified original reports of chemical interventions to prevent or treat hearing loss caused by noise exposure. An initial search returned 3492 articles. After excluding duplicate articles and articles that did not meet the systematic review inclusion criteria, a total of 213 studies published between 1977 and 2016 remained. Reference information, noise exposure parameters, species, sex, method of NIHL assessment, and pharmaceutical intervention details for these 213 studies were entered into a database. Frequency-specific threshold shifts in control animals (i.e., in the absence of pharmaceutical intervention) are reported here. Specific patterns of hearing loss as a function of species and noise exposure parameters are provided to facilitate the selection of appropriate pre-clinical models. The emphasis of this report is octave band noise exposure, as this is one of the most common exposure protocols across pharmacological otoprotection studies.
Reference Key
gittleman2019octavethe Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Gittleman, Sarah N;Le Prell, Colleen G;Hammill, Tanisha L;
Journal the journal of the acoustical society of america
Year 2019
DOI
10.1121/1.5133393
URL
Keywords
histopathology zoonosis pcr parasitic infection toxoplasmosis small ruminants

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