TiO Nanoparticle-Enhanced Linker Recombinant Strand Displacement Amplification (LRSDA) for Universal Label-Free Visual Bioassays.

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ID: 70238
2019
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Abstract
The influence of nanomaterials on dynamic isothermal amplification and their morphology regulated by bionic biological reactions in vitro remain unknown. From a theoretical perspective, TiO nanoparticles enhance the amplification efficiency and reaction specificity of recombinase polymerase amplification (RPA). These nanoparticles aggregated into larger nanoclusters by adsorbing RPA components, termed nanoscale RPA factories, which increased their local concentrations to enhance RPA. Following the nick/extension cycles mediated by a bifunctional linker located at the 5' end of the forward primers, the TiO nanoparticle-enhanced LRSDA process produces single-stranded products, constituting the G-quadruplex DNAzymes and catalyzing the chromogenic substrate to facilitate colorimetric analysis for on-site bioassays. spp. and genetically modified maize MON810 could be detected with a detection limit of 4 cfu/mL and 0.1% transgenic components, respectively. Briefly, TiO-assisted isothermal molecular amplification addressed the demands of practical on-site applications.
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tian2019tioacs Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Tian, Jingjing;Chu, Huashuo;Zhang, Yuan;Li, Kai;Tian, Hongtao;Zhang, Xiujie;Xu, Wentao;
Journal ACS applied materials & interfaces
Year 2019
DOI
10.1021/acsami.9b16314
URL
Keywords
adsorption label-free tio2 nanoparticle enhancement linker rpa versatile bioassays

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