Synthesis and anticancer activity of new substituted imidazolidinone sulfonamides

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2019
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Abstract
Obtained by the interaction of 2-amino-3,3-dichloroacrylonitrile and chlorosulphonyl isocyanate (Z)-(5-(dichloromethylene)-2-oxoimidazolidin-4-ylidene)sulfamoyl chloride reacts easily with excess of the aliphatic amine to form new (Z)-N-(5-(dichloromethylene)-2-oxoimidazolidin-4-ylidene)-N'-substituted sulfonamides. According to the National Cancer Institute (USA) examinations, two of the six synthesized sulfonamides showed a high anticancer activity.
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Authors Shablykin, Oleh V.;Kornii, Yurii Eu.;Dyakonenko, Victoriya V.;Shablykina, Olga V.;Brovarets, Volodymyr S.;
Journal current chemistry letters
Year 2019
DOI
DOI not found
URL
http://www.growingscience.com/ccl/Vol8/ccl_2019_18.pdf
Keywords
chemistry Microbiology Therapeutics. Pharmacology Biology (General) Medicine Pediatrics Science water supply for domestic and industrial purposes

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