Photoredox-Mediated Remote C(sp)-H Heteroarylation of -Alkyl Sulfonamides.

Clicks: 409
ID: 70145
2019
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Abstract
A Minisci-type δ-selective C(sp)-H heteroarylation of sulfonyl-protected primary aliphatic amines with -heteroarenes under photoredox-catalyzed conditions was developed. The reaction typically uses a slight excess of amine reactant. The use of benziodoxole acetate (BI-OAc) oxidant and hexafluoroisopropanol solvent is critical to achieve high yield. Besides methylene C-H bonds, heteroarylation reactions of δ methyl C-H bonds also worked under more forced conditions. The reactions show a broad scope for both amine and -heteroarene substrates, offering a straightforward method for synthesis of complex δ-heteroarylalkylmines from simple precursors.
Reference Key
deng2019photoredoxmediatedthe Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Deng, Zhiqiang;Li, Guo-Xing;He, Gang;Chen, Gong;
Journal The Journal of organic chemistry
Year 2019
DOI
10.1021/acs.joc.9b02502
URL
Keywords
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