Pyrazolone structural motif in medicinal chemistry: Retrospect and prospect.

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ID: 69954
2019
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Ranked #33 of 406 articles by views in European journal of medicinal chemistry

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Abstract
The pyrazolone structural motif is a critical element of drugs aimed at different biological end-points. Medicinal chemistry researches have synthesized drug-like pyrazolone candidates with several medicinal features including antimicrobial, antitumor, CNS (central nervous system) effect, anti-inflammatory activities and so on. Meanwhile, SAR (Structure-Activity Relationship) investigations have drawn attentions among medicinal chemists, along with a plenty of analogues have been derived for multiple targets. In this review, we comprehensively summarize the biological activity and SAR for pyrazolone analogues, wishing to give an overall retrospect and prospect on the pyrazolone derivatives.
Reference Key
zhao2019pyrazoloneeuropean Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Zhao, Zefeng;Dai, Xufen;Li, Chenyang;Wang, Xiao;Tian, Jiale;Feng, Ying;Xie, Jing;Ma, Cong;Nie, Zhuang;Fan, Peinan;Qian, Mingcheng;He, Xirui;Wu, Shaoping;Zhang, Yongmin;Zheng, Xiaohui;
Journal European journal of medicinal chemistry
Year 2019
DOI
S0223-5234(19)31045-1
URL
Keywords
Antimicrobial antitumor anti-inflammatory pyrazolone cns agents derivatives

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