Discovery of pyrazolone spirocyclohexadienone derivatives with potent antitumor activity.

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ID: 69953
2020
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Ranked #7 of 246 articles by views in Bioorganic & medicinal chemistry letters

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Abstract
Starting from easy accessible pyrazoletetrahydropyran acetals, a series of new pyrazolone spirocyclohexadienone derivatives were synthesized and assayed for antitumor activity. Compound 10s was identified to possess good antitumor activity. It could induce MDA-MB-231 cancer cell apoptosis in a concentration dependent manner and arrest the cell cycle progression mainly at the G1 phase.
Reference Key
wang2020discoverybioorganic Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Wang, Lei;Yang, Zixuan;Ni, Tianyu;Shi, Wencai;Guo, Yunbo;Li, Keliang;Shi, Anzhe;Wu, Shanchao;Sheng, Chunquan;
Journal Bioorganic & medicinal chemistry letters
Year 2020
DOI
S0960-894X(19)30612-2
URL
Keywords
antitumor structure-activity relationship pyrazolone spirocyclohexadienone

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