Molecules with versatile biological activities bearing antipyrinyl nucleus as pharmacophore.

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ID: 69951
2019
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Abstract
Antipyrine (1,2-dihydro-1,5-dimethyl-2-phenylpyrazole-3-one) in a structural frame consists of a five membered lactam pyrazolone heterocyclic ring as a pharmacophore moiety. It is evident from literature that the molecules having nitrogen bearing heterocyclic nuclei clearly exhibit several biological actions. Commercially available pyrazolone derivatives as drugs, analgin and metamizol are an established chemical class of analgesics. Recent trends of synthetic routes and several biological actions of antipyrine analogues are considered in this review. Indeed, the synthesized derivatives possess antipyrine moiety having versatile biological properties, antimicrobial, antitubercular, anthelmintic, antioxidant, analgesic, anti-inflammatory, cytotoxic and antiviral activities.
Reference Key
sahoo2019moleculeseuropean Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Sahoo, Jyotirmaya;Sahoo, Chita Ranjan;Nandini Sarangi, Priyambada Kshiroda;Prusty, Shakti Ketan;Padhy, Rabindra Nath;Paidesetty, Sudhir Kumar;
Journal European journal of medicinal chemistry
Year 2019
DOI
S0223-5234(19)31063-3
URL
Keywords
synthesis antipyrine pyrazolone schiffbase

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