Self-sufficient, low-cost microfluidic pumps utilising reinforced balloons.

Clicks: 298
ID: 69182
2019
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Abstract
Here, we introduce a simple method for increasing the inflation pressure of self-sufficient pressure pumps made of latex balloons. Our method involves reinforcing the latex balloon with elastane fibres to restrict the expansion of the balloon and increase its inflation pressure. This allowed us to increase the operational inflation pressure of a latex balloon from 2.5 to 25 kPa. Proof-of-concept experiments show the suitability of the reinforced balloon for inducing lateral forces and recirculating flows, which are employed for hydrodynamic capturing of large human monocytes. We also demonstrate the ability for the rapid exchange of solutions in repeated cycles upon manual squeezing of the reinforced balloons. We also show the suitability of the reinforced balloon for studying the mechanobiology of human aortic endothelial cells under various shear stress levels. The simplicity, portability, affordability, hyper-elasticity and scalability of the reinforced balloon pumps make them suitable for a wide range of microfluidic applications.
Reference Key
thurgood2019selfsufficientlab Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Thurgood, Peter;Suarez, Sergio Aguilera;Chen, Sheng;Gilliam, Christopher;Pirogova, Elena;Jex, Aaron R;Baratchi, Sara;Khoshmanesh, Khashayar;
Journal lab on a chip
Year 2019
DOI
10.1039/c9lc00618d
URL
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