Normoalbuminuric kidney impairment in patients with T1DM: insights from annals initiative

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ID: 68667
2018
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Abstract
Abstract Background We described, in a large sample of patients with type 1 diabetes mellitus (T1DM) and GFR ≤ 60 mL/min/1.73 m2 (with or without albuminuria), the differences in the clinical features associated with the two different chronic kidney disease phenotypes and we investigated, in a subset of patients, the modulating role of albuminuria on kidney disease progression. Methods Clinical data of 1395 patients with T1DM were extracted from electronic medical records. Results Albuminuria was detected in 676 (48.5%) patients, with the remaining 719 (51.5%) patients having normoalbuminuric renal impairment. Those with albuminuria showed an evident worse cardiovascular risk profile as compared to patients with normoalbuminuria. A subgroup of 582 patients was followed up over a 4-year period. One hundred and twenty five patients (21.5%) showed a loss of eGFR > 30%. The proportion of patients reaching the renal outcome was significantly higher among those with baseline albuminuria as compared to patients with normoalbuminuria (P < 0.0001). At the multivariate logistic analysis microalbuminuria, macroalbuminuria and proliferative retinopathy were the only parameters independently associated to eGFR reduction. Conclusions The proportion of T1DM patients with normoalbuminuria renal impairment is high (about 50%). These patients have a slower eGFR decline as compared to that observed in patients with albuminuria renal impairment.
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lamacchia2018normoalbuminuricdiabetology Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Lamacchia, Olga;Viazzi, Francesca;Fioretto, Paola;Mirijello, Antonio;Giorda, Carlo;Ceriello, Antonio;Russo, Giuseppina;Guida, Pietro;Pontremoli, Roberto;Cosmo, Salvatore De;
Journal diabetology & metabolic syndrome
Year 2018
DOI
DOI not found
URL
http://link.springer.com/article/10.1186/s13098-018-0361-2
Keywords
Medicine Pediatrics Science neurology. diseases of the nervous system nutritional diseases. deficiency diseases

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