Extrahepatic Manifestations and Autoantibodies in Patients with Hepatitis C Virus Infection

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ID: 68636
2012
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Abstract
Patients with chronic hepatitis C virus (HCV) infection frequently have many extrahepatic manifestations, as persistent HCV infection often triggers lymphoproliferative disorders and metabolic abnormalities. These manifestations primarily include autoimmune disorders such as cryoglobulinemia, Sjögren’s syndrome, and autoimmune thyroid disorders. It has been well established that chronic HCV infection plays important roles in the production of non-organ-specific autoantibodies, including antinuclear antibodies and smooth muscle antibodies, and organ-specific autoantibodies such as thyroid autoantibodies. However, the clinical significance of autoantibodies associated with the extrahepatic manifestations caused by HCV infection has not been fully recognized. In this paper, we mainly focus on the relationship between extrahepatic manifestations and the emergence of autoantibodies in patients with HCV infection and discuss the clinical relevance of the autoantibodies in the extrahepatic disorders.
Reference Key
himoto2012extrahepaticclinical Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Himoto, Takashi;Masaki, Tsutomu;
Journal clinical and developmental immunology
Year 2012
DOI
DOI not found
URL
http://dx.doi.org/10.1155/2012/871401
Keywords
Medicine Pediatrics Science Diseases of the circulatory (Cardiovascular) system Immunologic diseases. Allergy cytology

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