Lysosomal size matters.

Clicks: 297
ID: 68596
2019
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Abstract
Lysosomes are key cellular catabolic centers that also perform fundamental metabolic, signaling and quality control functions. Lysosomes are not static and they respond dynamically to intra- and extracellular stimuli triggering changes in organelle numbers, size and position. Such physical changes have a strong impact on lysosomal activity ultimately influencing cellular homeostasis. In this review, we summarize the current knowledge on lysosomal size regulation, on its physiological role(s) and association to several disease conditions.
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de-araujo2019lysosomaltraffic Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors de Araujo, Mariana E G;Liebscher, Gudrun;Hess, Michael W;Huber, Lukas A;
Journal traffic
Year 2019
DOI
10.1111/tra.12714
URL
Keywords
autophagy ampk fusion lysosome autolysosome borc lamtor pikfyve ptdins(3)p ptdins(3,5)p2 ptdins(4,5)p2 v-atpase endolysosome fission late endosome lysosomal acidification lysosomal reformation lysosomal storage disorders

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