Anti-Tumor Drug-Loaded Oxygen Nanobubbles for the Degradation of HIF-1α and the Upregulation of Reactive Oxygen Species in Tumor Cells.

Clicks: 478
ID: 68328
2019
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Abstract
Hypoxia is a key concern during the treatment of tumors, and hypoxia-inducible factor 1 alpha (HIF-1α) has been associated with increased tumor resistance to therapeutic modalities. In this study, doxorubicin-loaded oxygen nanobubbles (Dox/ONBs) were synthesized, and the effectiveness of drug delivery to MDA-MB-231 breast cancer and HeLa cells was evaluated. Dox/ONBs were characterized using optical and fluorescence microscopy, and size measurements were performed through nanoparticle tracking analysis (NTA). The working mechanism of Dox was evaluated using reactive oxygen species (ROS) assays, and cellular penetration was assessed with confocal microscopy. Hypoxic conditions were established to assess the effect of Dox/ONBs under hypoxic conditions compared with normoxic conditions. Our results indicate that Dox/ONBs are effective for drug delivery, enhancing oxygen levels, and ROS generation in tumor-derived cell lines.
Reference Key
khan2019antitumorcancers Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Khan, Muhammad Saad;Hwang, Jangsun;Lee, Kyungwoo;Choi, Yonghyun;Seo, Youngmin;Jeon, Hojeong;Hong, Jong Wook;Choi, Jonghoon;
Journal Cancers
Year 2019
DOI
E1464
URL
https://www.mdpi.com/2072-6694/11/10/1464
Keywords
Hypoxia drug delivery doxorubicin hypoxia-inducible factor 1 alpha oxygen nanobubbles

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