MoC combined with carbon material nanosphere as an electrochemiluminescence super-enhancer and antibody label for ultrasensitive detection of cardiac troponin I.

Clicks: 248
ID: 68301
2019
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #51 of 85 articles by views in Biosensors & bioelectronics

Most read Least read

Bar heights use a square-root scale.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
To sensitively detect cardiac troponin I (cTnI), a novel electrochemiluminescence (ECL) immunosensor was constructed on the basis of the core-shell MoC combined with carbon material (MoC@C) nanosphere as an ECL super-enhancer and a label of secondary antibody (Ab). MoC@C nanosphere with excellent conductivity and high chemical stability could increase the ECL intensity of the tris-(2,2'-bipyridine)ruthenium (Ru(bpy)). MoC@C/polyethylenimine (MoC@C/PEI) firmly anchored Ab by covalent bonding. Otherwise, amino-modified multiwall carbon nanotubes@nafion (MWCNTs-NH@N) composite film, as substrate material, could connect with the Ru(bpy) by ion exchange and immobilize primary antibodies (Ab) by amide bond. In addition, the boron nitride quantum dots (BNQDs) were utilized as the co-reactant, which were synthesized by using low-cost material melamine as a nitrogen source. Under optimal experimental conditions, the proposed ECL immunosensor possessed a low detection limit of 0.03 pg/mL (S/N = 3) and a wide linear range from 0.1 pg/mL to 50 ng/mL. The ultrasensitive ECL immunosensor had excellent stability, outstanding specificity and great reproducibility. It was also used to detect cTnI in human serum with satisfactory results.
Reference Key
wang2019mocbiosensors Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Wang, Luxiao;Xing, Bin;Ren, Xiang;Hu, Xun;Wang, Huan;Wu, Dan;Wei, Qin;
Journal Biosensors & bioelectronics
Year 2019
DOI
S0956-5663(19)30989-3
URL
Keywords
amino-modified multiwall carbon nanotubes boron nitride quantum dots cardiac troponin i electrochemiluminescence immunosensor mo(2)c combined with carbon material nanosphere

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.