A-kinase anchoring protein 1 (AKAP1) and its role in some cardiovascular diseases.

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ID: 67911
2019
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Ranked #12 of 18 articles by views in journal of molecular and cellular cardiology

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Abstract
A-kinase anchoring proteins (AKAPs) play crucial roles in regulating compartmentalized multi-protein signaling networks related to PKA-mediated phosphorylation. The mitochondrial AKAP - AKAP1 proteins are enriched in heart and play cardiac protective roles. This review aims to thoroughly summarize AKAP1 variants from their sequence features to the structure-function relationships between AKAP1 and its binding partners, as well as the molecular mechanisms of AKAP1 in cardiac hypertrophy, hypoxia-induced myocardial infarction and endothelial cells dysfunction, suggesting AKAP1 as a candidate for cardiovascular therapy.
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marin2019akinasejournal Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Wenwen Marin
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Journal journal of molecular and cellular cardiology
Year 2019
DOI
S0022-2828(19)30381-5
URL
Keywords
mitochondria cardiovascular diseases signaling a-kinase anchoring protein (akap)

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