Microbial production of (2R,3S)-isocitric acid: state of the arts and prospects.

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ID: 67497
2019
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Abstract
(2R,3S)-isocitric acid has long been used only as a specific biochemical reagent. However, there is ever increasing evidence that it can also be used as an original promising substance for prevention and treatment of some diseases. The review considers the results of longtime research in our laboratory and the data of other researchers related to microbial synthesis of (2R,3S)-isocitric acid, derivation and selection of active microbial producers, development of their cultivation conditions, as well as the results of study of the mechanism of acid overproduction, and regulation of enzymes involed in this process. The efficient processes of (2R,3S)-isocitric acid production with the aid of natural, mutant, and recombinant strains of Yarrowia lipolytica and methods of product isolation and purification to pharmacopeial standarts are also reviewed.
Reference Key
kamzolova2019microbialapplied Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Kamzolova, Svetlana V;Morgunov, Igor G;
Journal Applied microbiology and biotechnology
Year 2019
DOI
10.1007/s00253-019-10207-4
URL
Keywords
purification renewable resources (2r,3s)-isocitric acid actual technologies biotechnological production and application

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