SYNTHESIS, CHARACTERIZATION, UREASE INHIBITORY AND TYROSINASE INHIBITORY ACTIVITIES OF SOME CHIRAL PYRAZOLO DERIVATIVES

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ID: 6707
2017
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Abstract
A series of some pyrazolo derivatives (1-2)(a-f) were synthesized and their urease inhibitory and tyrosinase inhibitory activities were evaluated. Among synthesized compounds, 2f, 2e, 1f, 2d, 1e, 2b, and 1d showed excellent activities (IC50) i.e. 11.73±0.28, 14.21±0.56, 15.37±0.89, 17.66±0.82, 18.64±0.19, 19.55±0.39, and 22.08±0.96 μM, respectively. According to tyrosinase assay results, compound 2f showed the good tyrosinase inhibitory activity i.e. 6.12±0.40 mM of IC50.
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yusuf2017synthesisjournal Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Yusuf Sıcak;Yusuf Sıcak;Said Nadeem;Said Nadeem;Bedriye Seda Kurşun Aktar;Bedriye Seda Kurşun Aktar;Emine Elçin Oruç Emre;Emine Elçin Oruç Emre;Mehmet Öztürk;Mehmet Öztürk;Ayşegül Karaküçük İyidoğan;Ayşegül Karaküçük İyidoğan;Mehmet Ali Özler;Mehmet Ali Özler;İbrahim Demirtaş;İbrahim Demirtaş and
Journal journal of ongoing chemical research
Year 2017
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