[Application of polygenic risk scores in risk prediction and precision prevention of complex diseases: opportunities and challenges].

Clicks: 297
ID: 66654
2019
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Abstract
Along with the rapid progress in the field of human genomics, genome-wide association studies have successfully identified numerous risk loci for complex diseases. Polygenic risk scores can predict disease risk by integrating the effects of multiple susceptibility loci, and begin to show good performance for improving risk prediction, screening strategy and precision prevention. This paper briefly reviews the recent progress of polygenic risk scores in disease prevention, and summarizes the opportunities and challenges of its application.
Reference Key
hang2019applicationzhonghua Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Hang, D;Shen, H B;
Journal zhonghua liu xing bing xue za zhi = zhonghua liuxingbingxue zazhi
Year 2019
DOI
10.3760/cma.j.issn.0254-6450.2019.09.001
URL
Keywords
genome-wide association study complex diseases polygenic risk score precision prevention

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