Whither α-FP in the diagnosis of hepatocellular carcinoma?

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ID: 6657
2015
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Abstract
Whither α-FP in the diagnosis of hepatocellular carcinoma? Michael C Kew1,2 1Department of Medicine, Groote Schuur Hospital, University of Cape Town, Cape Town, 2University of the Witwatersrand, Johannesburg, South Africaα-FP is an α1-globulin present in high concentration in the fetal serum of mammals. It is the dominant plasma protein in the developing embryo, and is synthesized by the embryonal liver, by the endodermal cells of the visceral yolk sac, and, in very small amounts, by the embryonal intestine.1 Approximately 80% of fetal hepatocytes synthesize and secrete α-FP. The protein has been closely conserved throughout phylogenesis, suggesting that it has functions essential to the fetus, although precisely what these functions are remains to be learned. There does, however, appear to be an inverse relationship between serum α-FP and albumin levels, suggesting that α-FP might function as fetal albumin.2 Other possible biological properties of the α1-globulin include binding to estrogens and bilirubin, immunosuppressive activity, and a growth-promoting potential.3 The serum level of the protein remains constant until week 32, when it begins to sharply decrease. After birth, production of α-FP normally remains completely repressed, and serum concentrations are correspondingly very low.
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michael2015whithernbspalphafpjournal Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Michael C Kew and
Journal journal of hepatocellular carcinoma
Year 2015
DOI
10.2147/JHC.S91667
URL
Keywords Keywords not found

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