GPC-3 in hepatocellular carcinoma: current perspectives

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ID: 6645
2016
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Abstract
GPC-3 in hepatocellular carcinoma: current perspectives Yongle Wu,1 Hui Liu,2 Huiguo Ding1 1Department of Gastroenterology and Hepatology, 2Department of Pathology, Beijing You’an Hospital, Affiliated with Capital Medical University, Beijing, People’s Republic of China Abstract: Glypican-3 (GPC3), a member of heparan sulfate proteoglycans, attaches to the cell membrane and is frequently observed to be elevated in hepatocellular carcinoma (HCC). However, GPC3 is not detected in normal liver tissues and benign liver lesions. Consequently, GPC3 is currently being used as a diagnostic biomarker and HCC-specific positron emission computed tomography probe to identify HCCs in normal liver tissues and benign liver lesions. The overexpression of GPC-3 in serum or liver tissue also predicts poor prognosis for HCC patients. In addition, GPC3 promotes HCC growth and metastasis by activating the canonical Wnt and other signaling pathways. Targeting of GPC3, including GC33, HN3 and YP7, might offer new immunotherapeutic tools for HCC treatment. Keywords: glypican-3, hepatocellular carcinoma, diagnostics, prognosis, immunotherapy
Reference Key
yongle2016gpc3journal Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Yongle Wu;Hui Liu;Hui-Guo Ding and
Journal journal of hepatocellular carcinoma
Year 2016
DOI
10.2147/JHC.S116513
URL
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