Bioactive Natural Spirolactone-Type 6,7---Kaurane Diterpenoids and Synthetic Derivatives.

Clicks: 277
ID: 66439
2018
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Abstract
Diterpenoids are widely distributed natural products and have caused considerable interest because of their unique skeletons and antibacterial and antitumor activities and so on. In light of recent discoveries, -kaurane diterpenoids, which exhibit a wide variety of biological activities, such as anticancer and anti-inflammatory activities, pose enormous potential to serve as a promising candidate for drug development. Among them, spirolactone-type 6,7---kaurane diterpenoids, with interesting molecular skeleton, complex oxidation patterns, and bond formation, exhibit attractive activities. Furthermore, spirolactone-type diterpenoids have many modifiable sites, which allows for linking to various substituents, suitable for further medicinal study. Hence, some structurally modified derivatives with improved cytotoxicity activities are also achieved. In this review, natural bioactive spirolactone-type diterpenoids and their synthetic derivatives were summarized.
Reference Key
li2018bioactivemolecules Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Li, Haonan;Jiao, Runwei;Mu, Jiahui;Xu, Shengtao;Li, Xu;Wang, Xianhua;Li, Zhanlin;Xu, Jinyi;Hua, Huiming;Li, Dahong;
Journal molecules
Year 2018
DOI
E2914
URL
Keywords
natural product 6,7-seco-ent-kaurane diterpenoid spirolactone-type synthetic derivative

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