Mechanical and biological properties of the micro-/nano-grain functionally graded hydroxyapatite bioceramics for bone tissue engineering.

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ID: 65797
2015
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Abstract
Functionally graded materials (FGM) open the promising approach for bone tissue repair. In this study, a novel functionally graded hydroxyapatite (HA) bioceramic with micrograin and nanograin structure was fabricated. Its mechanical properties were tailored by composition of micrograin and nanograin. The dynamic mechanical analysis (DMA) indicated that the graded HA ceramics had similar mechanical property compared to natural bones. Their cytocompatibility was evaluated via fluorescent microscopy and MTT colorimetric assay. The viability and proliferation of rabbit bone marrow mesenchymal stem cells (BMSCs) on ceramics indicated that this functionally graded HA ceramic had better cytocompatibility than conventional HA ceramic. This study demonstrated that functionally graded HA ceramics create suitable structures to satisfy both the mechanical and biological requirements of bone tissues.
Reference Key
zhou2015mechanicaljournal Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Zhou, Changchun;Deng, Congying;Chen, Xuening;Zhao, Xiufen;Chen, Ying;Fan, Yujiang;Zhang, Xingdong;
Journal Journal of the mechanical behavior of biomedical materials
Year 2015
DOI
S1751-6161(15)00116-2
URL
Keywords
bone tissue engineering functionally graded materials biological property mechanical property two-step sintering

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