Hemostatic complications associated with ventricular assist devices.

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ID: 65541
2019
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Abstract
Hemostatic complications are common in patients with ventricular assist devices. The pathophysiologic mechanisms that lead to dysregulated hemostasis involve complex interactions between device surface, sheer stress, and blood flow. These factors lead to various manifestations that require a thorough understanding of the interplay among platelets, coagulation factors, and red cells. In this article, we review the pathophysiology of hematologic complications (bleeding, acquired von Willebrand disease, heparin-induced thrombocytopenia, hemolysis, stroke and pump thrombosis), the clinical manifestations, and the management of each. We summarize the evidence available for management of these entities and provide a pragmatic clinical review.
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hilal2019hemostaticresearch Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Hilal, Talal;Mudd, James;DeLoughery, Thomas G;
Journal research and practice in thrombosis and haemostasis
Year 2019
DOI
10.1002/rth2.12226
URL
Keywords
hemostasis thrombosis heart-assist devices heparin‐induced thrombocytopenia ventricular assist devices von willebrand diseases

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