Newborn DNA-methylation, childhood lung function, and the risks of asthma and COPD across the life course.

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ID: 65520
2019
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Abstract
We aimed to identify differentially methylated regions (DMRs) in cord blood DNA associated with childhood lung function, asthma and chronic obstructive pulmonary disease (COPD) across the life course.We meta-analysed epigenome-wide data of 1688 children from five cohorts to identify cord blood DMRs and their annotated genes, in relation to forced expiratory volume in 1 s (FEV), FEV/forced vital capacity (FVC) ratio and forced expiratory flow at 75% of FVC at ages 7-13 years. Identified DMRs were explored for associations with childhood asthma, adult lung function and COPD, gene expression and involvement in biological processes.We identified 59 DMRs associated with childhood lung function, of which 18 were associated with childhood asthma and nine with COPD in adulthood. Genes annotated to the top 10 identified DMRs were , , , , , , , , and . Differential gene expression in blood was observed for 32 DMRs in childhood and 18 in adulthood. Genes related with 16 identified DMRs were associated with respiratory developmental or pathogenic pathways.Our findings suggest that the epigenetic status of the newborn affects respiratory health and disease across the life course.
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den-dekker2019newbornthe Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors den Dekker, Herman T;Burrows, Kimberley;Felix, Janine F;Salas, Lucas A;Nedeljkovic, Ivana;Yao, Jin;Rifas-Shiman, Sheryl L;Ruiz-Arenas, Carlos;Amin, N;Bustamante, Mariona;DeMeo, Dawn L;Henderson, A John;Howe, Caitlin G;Hivert, Marie-France;Ikram, M Arfan;de Jongste, Johan C;Lahousse, Lies;Mandaviya, Pooja R;van Meurs, Joyce B;Pinart, Mariona;Sharp, Gemma C;Stolk, Lisette;Uitterlinden, André G;Anto, Josep M;Litonjua, Augusto A;Breton, Carrie V;Brusselle, Guy G;Sunyer, Jordi;Smith, George Davey;Relton, Caroline L;Jaddoe, Vincent W V;Duijts, Liesbeth;
Journal The European respiratory journal
Year 2019
DOI
1801795
URL
Keywords
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