NHC-Catalyzed Asymmetric Formal [4 + 2] Annulation To Construct Spirocyclohexane Pyrazolone Skeletons.

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ID: 64662
2019
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Abstract
A chiral N-heterocyclic carbene (NHC)-catalyzed [4 + 2] annulation of γ-chloroenals and α-arylidene pyrazolinones was developed in the absence of expensive oxidants. The reaction proceeds smoothly via a vinyl enolate intermediate to afford spirocyclohexane pyrazolones in moderate to good yield (up to 86%) with high diastereoselectivities (up to 15:1 ) and excellent enantioselectivities (up to >99% ).
Reference Key
zhao2019nhccatalyzedorganic Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Zhao, Chengtao;Shi, Kuangxi;He, Gao;Gu, Qingxiu;Ru, Zhenyuan;Yang, Limin;Zhong, Guofu;
Journal Organic letters
Year 2019
DOI
10.1021/acs.orglett.9b02927
URL
Keywords
uplc-ms/ms monosaccharide composition polyporus umbellatus polysaccharide pre-column derivation

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