Prenatal exposure to artificial food colorings alters NMDA receptor subunit concentrations in rat hippocampus.

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ID: 64642
2019
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Abstract
Exposure to artificial food color additives (AFCAs) has been implicated in the etiology of certain childhood hyperactivity and learning disabilities. N-methyl-D-aspartate receptors and alpha-7 nicotinic acetylcholine receptor (α7 nAChR) are involved in learning and memory. We administered a mixture of AFCAs (erythrosine, ponceau 4R, allura red AC, sunset yellow FCF, tartrazine, amaranth, brilliant blue, azorubine, and indigotine) to female rats during gestation to investigate the effects of prenatal exposure to AFCAs on neurobehavior, spatial learning, and memory in their offspring. We also investigated whether AFCAs modulate NR2A, NR2B, and α7 nAChR protein levels in their offsprings' hippocampi. Although spatial learning and memory were not altered, the offspring of rats exposed to AFCAs exhibited decreased motivation and increased despair-related behavior. NR2A and NR2B protein levels were significantly reduced in female offspring in the experimental group ( < 0.05), whereas α7 nAChR level was not significantly altered. Our results suggest that prenatal exposure to AFCAs may lead to sex-dependent alterations in glutamatergic signaling which may continue into adolescence.
Reference Key
doguc2019prenatalnutritional Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Doguc, Duygu Kumbul;Deniz, Firdevs;İlhan, İlter;Ergonul, Esin;Gultekin, Fatih;
Journal nutritional neuroscience
Year 2019
DOI
10.1080/1028415X.2019.1681065
URL
Keywords
nmdars forced swim test spatial learning and memory artificial food colors nr2a nr2b open field test α7 nachr

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