Aggregated aluminium exposure: risk assessment for the general population.

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ID: 64557
2019
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Abstract
Aluminium is one of the most abundant elements in earth's crust and its manifold uses result in an exposure of the population from many sources. Developmental toxicity, effects on the urinary tract and neurotoxicity are known effects of aluminium and its compounds. Here, we assessed the health risks resulting from total consumer exposure towards aluminium and various aluminium compounds, including contributions from foodstuffs, food additives, food contact materials (FCM), and cosmetic products. For the estimation of aluminium contents in foodstuff, data from the German "Pilot-Total-Diet-Study" were used, which was conducted as part of the European TDS-Exposure project. These were combined with consumption data from the German National Consumption Survey II to yield aluminium exposure via food for adults. It was found that the average weekly aluminium exposure resulting from food intake amounts to approx. 50% of the tolerable weekly intake (TWI) of 1 mg/kg body weight (bw)/week, derived by the European Food Safety Authority (EFSA). For children, data from the French "Infant Total Diet Study" and the "Second French Total Diet Study" were used to estimate aluminium exposure via food. As a result, the TWI can be exhausted or slightly exceeded-particularly for infants who are not exclusively breastfed and young children relying on specially adapted diets (e.g. soy-based, lactose free, hypoallergenic). When taking into account the overall aluminium exposure from foods, cosmetic products (cosmetics), pharmaceuticals and FCM from uncoated aluminium, a significant exceedance of the EFSA-derived TWI and even the PTWI of 2 mg/kg bw/week, derived by the Joint FAO/WHO Expert Committee on Food Additives, may occur. Specifically, high exposure levels were found for adolescents aged 11-14 years. Although exposure data were collected with special regard to the German population, it is also representative for European and comparable to international consumers. From a toxicological point of view, regular exceedance of the lifetime tolerable aluminium intake (TWI/PTWI) is undesirable, since this results in an increased risk for health impairments. Consequently, recommendations on how to reduce overall aluminium exposure are given.
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tietz2019aggregatedarchives Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Tietz, Thomas;Lenzner, Ariane;Kolbaum, Anna Elena;Zellmer, Sebastian;Riebeling, Christian;Gürtler, Rainer;Jung, Christian;Kappenstein, Oliver;Tentschert, Jutta;Giulbudagian, Michael;Merkel, Stefan;Pirow, Ralph;Lindtner, Oliver;Tralau, Tewes;Schäfer, Bernd;Laux, Peter;Greiner, Matthias;Lampen, Alfonso;Luch, Andreas;Wittkowski, Reiner;Hensel, Andreas;
Journal archives of toxicology
Year 2019
DOI
10.1007/s00204-019-02599-z
URL
Keywords
Children risk assessment infants adults dietary exposure cosmetics aluminium food contact materials toxicological overview

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