Safety evaluation of calcium L-methylfolate.

Clicks: 379
ID: 64550
2019
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #8 of 22 articles by views in toxicology reports

Most read Least read

Bar heights use a square-root scale.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Calcium L-methylfolate (L-5-MTHF-Ca; CAS Number 151533-22-1) is a source of folate and an alternative to folic acid for use in human food and food supplements. The safety of L-5-MTHF-Ca was evaluated by testing for genotoxicity, subchronic and prenatal developmental toxicity. In assays L-5-MTHF-Ca was not mutagenic and did not induce other chromosomal events. Additionally, L-5-MTHF-Ca was not genotoxic in the micronucleus test nor did it induce DNA damage in rat liver cells. In a subchronic toxicity study, rats administered up to 400 mg/kg bw/day of L-5-MTHF-Ca oral gavage for 13 weeks had no treatment-related mortalities, and no treatment-related effects were identified on behaviour, body weight, food consumption, ophthalmology, haematology, or organ weights. No treatment-related macroscopic or histopathological findings were observed. Calcium and sodium levels increased with increasing dosage, however the slight increases were within historical control ranges and reversible after the recovery period. L-5-MTHF-Ca is neither teratogenic nor embryotoxic. Based on the results of the and studies, the safe use of L-5-MTHF-Ca as an ingredient in foods is supported. The no observed adverse effect level was the highest dose in the subchronic toxicity study, 400 mg/kg bw/day for male and female rats.
Reference Key
niederberger2019safetytoxicology Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Niederberger, K E;Dahms, I;Broschard, T H;Boehni, R;Moser, R;
Journal toxicology reports
Year 2019
DOI
10.1016/j.toxrep.2019.09.012
URL
Keywords
toxicity developmental toxicity genotoxicity 5-mthf, 5-methyltetrahydrofolate anova, analysis of variance bap, benzo[a]pyrene calcium l-methylfolate efsa, european food safety authority gd, gestation day glp, good laboratory practice gras, generally recognized as safe hplc, high performance liquid chromatography jecfa, joint fao/who expert committee on food additives l-5-mthf-ca l-5-mthf-ca, calcium l-methylfolate mtt, 3-[45-dimethylthiazole-2-yl]-2,5-diphenylbromide nng, net grains/nucleus noael, no observed adverse effect level oecd, organisation for economic co-operation and development tft, 5-trifluorothymidine usp, united states pharmacopeia we-i, williams e medium-incomplete bw, body weight

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.