Theoretical design, preparation and evaluation of Ginkgolide B molecularly imprinted polymers.

Clicks: 328
ID: 64475
2019
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Abstract
Ginkgolide B is in great demand worldwide on account of its extensive and excellent pharmacological effects, however, it is difficult to separate and purify ginkgolide B. In this study, ginkgolide B molecularly imprinted polymers were prepared by combining software simulation and molecular imprinting technique, and its characterization and adsorption performed evaluation were performed to understand the adsorption behavior of the polymers. The adsorption equilibrium concentration of molecularly imprinted polymers was 0.70 mg/mL, and the adsorption equilibrium time was 4 h. Meanwhile, the adsorption isotherm of the polymers for ginkgolide B fitted well with the Langmuir model, and the adsorption kinetics was in line with the pseudo-second-order kinetics. In contrast, the adsorption capacity of molecularly imprinted polymers on ginkgolide B was higher than that of non-molecular imprinted polymers, with better selectivity and better adsorption after repeated use for 6 times. The application experiments showed that molecular imprinted polymers have a good adsorption effect in low purity samples. Therefore, the polymers reported herein can be expected to apply in the adsorption and separation of ginkgolide B samples. This article is protected by copyright. All rights reserved.
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Authors Li, Honghong;Zhang, Wencheng;Wu, Zeyu;Huang, Xusheng;Hui, Ailing;He, Yiwen;Wang, Haiyan;
Journal journal of separation science
Year 2019
DOI
10.1002/jssc.201900675
URL
Keywords
Simulation ginkgolide b adsorption capacity molecularly imprinted polymers

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