Discovery of Novel Isothiazole, 1,2,3-Thiadiazole, and Thiazole-Based Cinnamamides as Fungicidal Candidates.

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ID: 64096
2019
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Abstract
A series of isothiazole, 1,2,3-thiadiazole, and thiazole-based cinnamamide morpholine derivatives were rationally designed, synthesized, characterized, and evaluated for their fungicidal activities. Bioassay indicated that a combination of 3,4-dichloroisothiazole active substructures with cinnamamide morpholine lead to significant improvement of in vivo antifungal activities of the target compounds; among them, compound exhibited good fungicidal activity against in vivo with an inhibition rate of 100% at 100 μg/mL. A field experiment indicated that the difference of efficacy between (75.9%) and dimethomorph (77.1%) at 37.5 g ai/667 m was not significant; and also exhibited good activity against by triggering accumulation of and defense-related gene expression and the defense associated enzyme phenylalanine ammonia-lyase (PAL) expression on cucumber, rather than direct inhibition. These findings strongly supported that 3,4-dichloroisothiazole containing cinnamamide morpholine not only showed good fungicidal activity against but also exhibited plant innate immunity stimulation activity as a promising fungicide candidate with both fungicidal activity and systemic acquired resistance.
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Authors Chen, Lai;Zhao, Bin;Fan, Zhijin;Hu, Mengxu;Li, Qing;Hu, Wenhao;Li, Jiwei;Zhang, Jinlin;
Journal Journal of agricultural and food chemistry
Year 2019
DOI
10.1021/acs.jafc.9b03891
URL
Keywords
cinnamamide 1,2,3-thiadiazole 3,4-dichloroisothiazole elicitor fungicidal activity

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