General Synthesis of 1-Aryl-6-azaisocytosines and Their Utilization for the Preparation of Related Condensed 1,2,4-Triazines.

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ID: 64056
2019
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Abstract
A simple general synthesis of 1-aryl-6-azaisocytosine-5-carbonitriles is described. This method is based on coupling diazonium salts with cyanoacetylcyanamide and then cyclization of the formed 2-arylhydrazono-2-cyanoacetylcyanamides . The 6-azaisocytosines were studied with respect to tautomeric equilibrium and the transformation of functional groups, and used in the synthesis of the condensed heterocyclic compounds: Purine isosteric imidazo[2,1-]-[1,2,4]triazine and the 1,2,4-triazino[2,3-]quinazolines -.
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zlek2019generalmolecules Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Zálešák, František;Slouka, Jan;Stýskala, Jakub;
Journal molecules
Year 2019
DOI
E3558
URL
Keywords
1,2,4-triazine 1-aryl-6-azaisocytosine condensed 1,2,4-triazine cyclization of arylhydrazones fused azaisocytosines

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