New Approach for the One-Pot Synthesis of 1,3,5-Triazine Derivatives: Application of Cu(I) Supported on a Weakly Acidic Cation-Exchanger Resin in a Comparative Study.

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ID: 64052
2019
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Abstract
An efficient and simple methodology for Ullmann Cu(I)-catalyzed synthesis of di- and trisubstituted 1,3,5-triazine derivatives from dichlorotriazinyl benzenesulfonamide and corresponding nucleophiles is reported. Cations Cu(I) supported on macroporous and weakly acidic, low-cost industrial resin of polyacrylate type were used as a catalyst. The reaction times and yields were compared with traditional synthetic methods for synthesis of substituted 1,3,5-triazine derivatives via nucleophilic substitution of chlorine atoms in dichlorotriazinyl benzenesulfonamide. It was found that Ullmann-type reactions provide significantly shortened reaction times and, in some cases, also higher yields. Finally, trisubstituted -triazine derivatives were effectively prepared via Ullmann-type reaction in a one-pot synthetic design. Six new -triazine derivatives with potential biological activity were prepared and characterized.
Reference Key
havrnkov2019newmolecules Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Havránková, Eva;Csöllei, Jozef;Pazdera, Pavel;
Journal molecules
Year 2019
DOI
E3586
URL
Keywords
one-pot synthesis 1,3,5-triazine ullmann reaction supported cu(i) catalyst

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