Thrombosis in the Philadelphia Chromosome-Negative Myeloproliferative Neoplasms.

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ID: 63780
2019
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Abstract
The myeloproliferative neoplasms (MPNs) are clonal stem cell-derived diseases. This chapter focuses on the subcategory of Philadelphia (Ph) chromosome-negative classical MPNs, polycythemia vera (PV), essential thrombocythemia (ET), primary myelofibrosis (PMF). These MPNs are associated with both microvascular and macrovascular thrombosis, which may occur in the venous and arterial circulation. Erythrocytosis, leukocytosis, and increased JAK2V617F allele burden are known to be risk factors. In this chapter, we review the thrombotic and hemostatic manifestations of the Philadelphia (Ph) chromosome-negative classical MPNs, including the clinical manifestations, the pathophysiology, as well as management.
Reference Key
sankar2019thrombosiscancer Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Sankar, Kamya;Stein, Brady L;Rampal, Raajit K;
Journal cancer treatment and research
Year 2019
DOI
10.1007/978-3-030-20315-3_11
URL
Keywords
myeloproliferative neoplasms myelofibrosis essential thrombocythemia jak2v617f macrovascular thrombosis microvascular thrombosis polycythemia vera

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