Ca-independent but voltage-dependent quantal catecholamine secretion (CiVDS) in the mammalian sympathetic nervous system.

Clicks: 302
ID: 63722
2019
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #98 of 292 articles by views in Proceedings of the National Academy of Sciences of the United States of America

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 292 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Action potential-induced vesicular exocytosis is considered exclusively Ca dependent in Katz's Ca hypothesis on synaptic transmission. This long-standing concept gets an exception following the discovery of Ca-independent but voltage-dependent secretion (CiVDS) and its molecular mechanisms in dorsal root ganglion sensory neurons. However, whether CiVDS presents only in sensory cells remains elusive. Here, by combining multiple independent recordings, we report that [1] CiVDS robustly presents in the sympathetic nervous system, including sympathetic superior cervical ganglion neurons and slice adrenal chromaffin cells, [2] uses voltage sensors of Ca channels (N-type and novel L-type), and [3] contributes to catecholamine release in both homeostatic and fight-or-flight like states; [4] CiVDS-mediated catecholamine release is faster than that of Ca-dependent secretion at the quantal level and [5] increases Ca currents and contractility of cardiac myocytes. Together, CiVDS presents in the sympathetic nervous system with potential physiological functions, including cardiac muscle contractility.
Reference Key
huang2019caindependentproceedings Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Huang, Rong;Wang, Yuan;Li, Jie;Jiang, Xiaohan;Li, Yinglin;Liu, Bing;Wu, Xi;Du, Xingyu;Hang, Yuqi;Jin, Mu;Zhu, Feipeng;Wang, Changhe;Chai, Zuying;Zhou, Zhuan;
Journal Proceedings of the National Academy of Sciences of the United States of America
Year 2019
DOI
10.1073/pnas.1902444116
URL
Keywords
civds n-type and l-type ca2+ channels catecholamine chromaffin cells sympathetic neurons

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.