Copper-Doped Nano Laponite Coating on Poly(butylene Succinate) Scaffold with Antibacterial Properties and Cytocompatibility for Biomedical Application

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ID: 63623
2018
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Abstract
An ideal artificial bone will likely be multifunctional, combining different technologies to simultaneously promote bone regeneration while inhibiting microbial infection. In this study, copper- (Cu-) doped nano laponite (cnLAP) was prepared by a cation-exchanged method, and the cnLAP coating on poly(butylene succinate) (PBSu) scaffold was fabricated by poly(dopamine) modification. The results showed that incorporation of Cu ions into nano laponite (nLAP) did not have obvious effects on the morphology and surface area of cnLAP (compared with nLAP), which could be coated easily on macroporous PBSu scaffolds. In addition, the cnLAP-coated PBSu scaffolds could inhibit the growth of both Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus), indicating good antibacterial activity. Moreover, the cnLAP-coated PBSu scaffolds significantly promoted proliferation and improved alkaline phosphatase (ALP) activity of bone mesenchymal stem cells (BMSCs) compared with PBSu scaffolds. Furthermore, no obvious differences in cell responses to cnLAP- and nLAP-coated PBSu scaffolds were found, indicating that incorporation of Cu into nLAP had no negative effects on its cytocompatibility. The results suggested that the cnLAP-coated PBSu scaffolds exhibited excellent cytocompatibility and antimicrobial activity, which might offer promising opportunities for promoting bone regeneration and prevention of infectious from bacteria and effective treatment of bone defects.
Reference Key
tang2018copperdopedjournal Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Tang, Xiaoming;Dai, Jian;Sun, Hailang;Nabanita, Saha;Petr, Saha;Tang, Liangchen;Cheng, Qilin;Wang, Deqiang;Wei, Jie;
Journal journal of nanomaterials
Year 2018
DOI
DOI not found
URL
http://dx.doi.org/10.1155/2018/5470814
Keywords
chemistry Therapeutics. Pharmacology Biology (General) Medicine Technology (General) Science

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