Geographic Variability and Anti-Staphylococcal Activity of the Chrysophaentins and Their Synthetic Fragments

Clicks: 197
ID: 63615
2012
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Steady

Ranked #70 of 132 articles by views in Marine drugs

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 132 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Drug-resistant <em>Staphylococcus aureus</em> is a continuing public health concern, both in the hospital and community settings. Antibacterial compounds that possess novel structural scaffolds and are effective against multiple <em>S. aureus</em> strains, including current drug-resistant ones, are needed. Previously, we have described the chrysophaentins, a family of bisdiarylbutene macrocycles from the chrysophyte alga <em>Chrysophaeum taylori</em> that inhibit the growth of <em>S. aureus</em> and methicillin-resistant <em>S. aureus</em> (MRSA). In this study we have analyzed the geographic variability of chrysophaentin production in <em>C. taylori</em> located at different sites on the island of St. John, U.S. Virgin Islands, and identified two new linear chrysophaentin analogs, E2 and E3. In addition, we have expanded the structure activity relationship through synthesis of fragments comprising conserved portions of the chrysophaentins, and determined the antimicrobial activity of natural chrysophaentins and their synthetic analogs against five diverse <em>S. aureus</em> strains. We find that the chrysophaentins show similar activity against all <em>S. aureus</em> strains, regardless of their drug sensitivity profiles. The synthetic chrysophaentin fragments indeed mimic the natural compounds in their spectrum of antibacterial activity, and therefore represent logical starting points for future medicinal chemistry studies of the natural products and their analogs.
Reference Key
hammill2012geographicmarine Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Hammill, Jared T.;Lloyd, John R.;Bewley, Carole A.;Wipf, Peter;Plaza, Alberto;Keffer, Jessica L.;
Journal Marine drugs
Year 2012
DOI
DOI not found
URL
http://www.mdpi.com/1660-3397/10/5/1103
Keywords
Biology (General)

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.