Novel thymol bearing oxypropanolamine derivatives as potent some metabolic enzyme inhibitors - Their antidiabetic, anticholinergic and antibacterial potentials.

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ID: 62865
2018
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Abstract
A series of classical and newly synthesized thymol bearing oxypropanolamine compounds were synthesized and characterized. Their in vitro antibacterial activity on A. baumannii, P. aeruginosa, E. coli and S. aureus strains were investigated with agar well diffusion method. The results were compared with commercially available drug active compounds. As well as 3a, 3b and 3c have the most significant antibacterial effect among all the tested compounds; approximately all of them have more antibacterial activity than the reference drugs. These novel thymol bearing oxypropanolamine derivatives were effective inhibitors of the α-glycosidase, cytosolic carbonic anhydrase I and II isoforms (hCA I and II), and acetylcholinesterase enzymes (AChE) with K values in the range of 463.85-851.05 µM for α-glycosidase, 1.11-17.34 µM for hCA I, 2.97-17.83 µM for hCA II, and 13.58-31.45 µM for AChE, respectively.
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zengin2018novelbioorganic Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Zengin, Mustafa;Genc, Hayriye;Taslimi, Parham;Kestane, Ali;Guclu, Ertugrul;Ogutlu, Aziz;Karabay, Oguz;Gulçin, İlhami;
Journal Bioorganic chemistry
Year 2018
DOI
S0045-2068(18)30564-9
URL
Keywords
acetylcholinesterase carbonic anhydrase antibacterial effects α-glycosidase oxypropanolamine

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