Novel eugenol bearing oxypropanolamines: Synthesis, characterization, antibacterial, antidiabetic, and anticholinergic potentials.

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ID: 62864
2019
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Abstract
Five oxypropanol amine derivatives that four of them are novel have been synthesized with high yields and practical methods. in vitro antibacterial susceptibility of Acinetobacter baumannii, Pseudomonas aeruginosa, Escherichia coli and Staphylococcus aureus strains to synthesized substances were evaluated with agar well-diffusion method by comparison with commercially available drugs. Most of the bacteria were multidrug resistant. It was concluded that these compounds are much more effective than reference drugs. These eugenol bearing oxypropanolamine derivatives were also effective inhibitors against α-glycosidase, cytosolic carbonic anhydrase I and II isoforms (hCA I and II), and acetylcholinesterase (AChE) enzymes with K values in the range of 0.80 ± 0.24-3.52 ± 1.01 µM for hCA I, 1.08 ± 0.15-3.64 ± 0.92 µM for hCA II, 5.18 ± 0.84-12.46 ± 2.08 µM for α-glycosidase, and 11.33 ± 2.83-32.81 ± 9.73 µM for AChE, respectively.
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genc-bilgicli2019novelbioorganic Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Genç Bilgiçli, Hayriye;Kestane, Ali;Taslimi, Parham;Karabay, Oguz;Bytyqi-Damoni, Arlinda;Zengin, Mustafa;Gulçin, İlhami;
Journal Bioorganic chemistry
Year 2019
DOI
S0045-2068(18)30950-7
URL
Keywords
enzyme inhibition acetylcholinesterase eugenol carbonic anhydrase antibacterial effects α-glycosidase

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