Integrative structure and functional anatomy of a nuclear pore complex.

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ID: 62119
2018
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Abstract
Nuclear pore complexes play central roles as gatekeepers of RNA and protein transport between the cytoplasm and nucleoplasm. However, their large size and dynamic nature have impeded a full structural and functional elucidation. Here we determined the structure of the entire 552-protein nuclear pore complex of the yeast Saccharomyces cerevisiae at sub-nanometre precision by satisfying a wide range of data relating to the molecular arrangement of its constituents. The nuclear pore complex incorporates sturdy diagonal columns and connector cables attached to these columns, imbuing the structure with strength and flexibility. These cables also tie together all other elements of the nuclear pore complex, including membrane-interacting regions, outer rings and RNA-processing platforms. Inwardly directed anchors create a high density of transport factor-docking Phe-Gly repeats in the central channel, organized into distinct functional units. This integrative structure enables us to rationalize the architecture, transport mechanism and evolutionary origins of the nuclear pore complex.
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kim2018integrativenature Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Kim, Seung Joong;Fernandez-Martinez, Javier;Nudelman, Ilona;Shi, Yi;Zhang, Wenzhu;Raveh, Barak;Herricks, Thurston;Slaughter, Brian D;Hogan, Joanna A;Upla, Paula;Chemmama, Ilan E;Pellarin, Riccardo;Echeverria, Ignacia;Shivaraju, Manjunatha;Chaudhury, Azraa S;Wang, Junjie;Williams, Rosemary;Unruh, Jay R;Greenberg, Charles H;Jacobs, Erica Y;Yu, Zhiheng;de la Cruz, M Jason;Mironska, Roxana;Stokes, David L;Aitchison, John D;Jarrold, Martin F;Gerton, Jennifer L;Ludtke, Steven J;Akey, Christopher W;Chait, Brian T;Sali, Andrej;Rout, Michael P;
Journal Nature
Year 2018
DOI
10.1038/nature26003
URL
Keywords
articular cartilage transforming growth factor β intergenerational transmission histone deacetylation modification nicotine prenatal exposure

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