1,4-Naphthoquinones: From Oxidative Damage to Cellular and Inter-Cellular Signaling

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ID: 61853
2014
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Abstract
Naphthoquinones may cause oxidative stress in exposed cells and, therefore, affect redox signaling. Here, contributions of redox cycling and alkylating properties of quinones (both natural and synthetic, such as plumbagin, juglone, lawsone, menadione, methoxy-naphthoquinones, and others) to cellular and inter-cellular signaling processes are discussed: (i) naphthoquinone-induced Nrf2-dependent modulation of gene expression and its potentially beneficial outcome; (ii) the modulation of receptor tyrosine kinases, such as the epidermal growth factor receptor by naphthoquinones, resulting in altered gap junctional intercellular communication. Generation of reactive oxygen species and modulation of redox signaling are properties of naphthoquinones that render them interesting leads for the development of novel compounds of potential use in various therapeutic settings.
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Authors Klotz, Lars-Oliver;Hou, Xiaoqing;Jacob, Claus;
Journal molecules
Year 2014
DOI
DOI not found
URL
http://www.mdpi.com/1420-3049/19/9/14902
Keywords
Organic Chemistry Microbiology Medicine Science Diseases of the blood and blood-forming organs ophthalmology nutrition. foods and food supply

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