Stacking as a Key Property for Creating Nanoparticles with Tunable Shape: The Case of Squalenoyl-Doxorubicin.

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ID: 61396
2019
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Abstract
The development of elongated nanoparticles for drug delivery is of growing interest in recent years, due to longer blood circulation and improved efficacy compared to spherical counterparts. Squalenoyl-doxorubicin (SQ-Dox) conjugate was previously shown to form elongated nanoparticles with improved therapeutic efficacy and decreased toxicity compared to free doxorubicin. By using experimental and computational techniques, we demonstrate here that the specific physical properties of SQ-Dox, which include stacking and electrostatic interactions of doxorubicin as well as hydrophobic interactions of squalene, are involved in the formation of nanoassemblies with diverse elongated structures. We show that SQ-Dox bioconjugate concentration, ionic strength, and anion nature can be used to modulate the shape and stiffness of SQ-Dox nanoparticles. As those parameters are involved in nanoparticle behavior in biological media, these findings could bring interesting opportunities for drug delivery and serve as an example for the design of original nanodrugs with stacking properties tuned for particular clinical purposes.
Reference Key
mougin2019stackingacs Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Mougin, Julie;Yesylevskyy, Semen O;Bourgaux, Claudie;Chapron, David;Michel, Jean-Philippe;Dosio, Franco;Stella, Barbara;Ramseyer, Christophe;Couvreur, Patrick;
Journal acs nano
Year 2019
DOI
10.1021/acsnano.9b05303
URL
Keywords
doxorubicin nanomedicine bioconjugate cylindrical nanoparticles elongated nanoparticles squalene stacking

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