Smartphone controlled interactive portable device for theranostics in vitro.

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ID: 61390
2019
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Abstract
In this work, a smartphone controlled interactive theranostic device has been developed to perform in vitro photodynamic therapy (PDT) and diagnostic assays for treatment assessment on a single platform. Further, silver nanorod (Ag NR) was identified as a photosensitizer and its effect was studied in three different cell lines. PDT was achieved with Ag NRs using low irradiation (1.4 mW/cm at 632 nm) from light emitting diodes (LEDs) in the device. Specifically, PDT in conjugation with widely used chemotherapeutic drug doxorubicin (Dox) proved effective in killing of HeLa cancer cells and multicellular tumor spheroids at a minimum dose of Ag (2.5 μg/mL). The MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) and LDH (lactate dehydrogenase) assays performed with the device indicated the therapeutic success of the delivered PDT. The device is portable and can be adapted for different wavelength irradiations and radiation doses. Additionally, wireless operation using a custom designed smartphone application makes it convenient to use in complex environments without much of human intervention.
Reference Key
sailapu2019smartphonebiosensors Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Sailapu, Sunil Kumar;Dutta, Deepanjalee;Simon, Anitha T;Ghosh, Siddhartha Sankar;Chattopadhyay, Arun;
Journal Biosensors & bioelectronics
Year 2019
DOI
S0956-5663(19)30824-3
URL
Keywords
smartphone LED diagnosis photodynamic therapy portable device theranostics colorimetric assays

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